ai.nullary/nullary

可用工具

• search_inactive_compoundsInactive small-molecule compound-target pairs.
• search_failed_selectivitySmall molecules that failed selectivity.
• search_admet_failuresSmall-molecule ADMET failures.
• search_failed_guidesFailed/ineffective CRISPR guides.
• search_failed_essentiality_screensNon-dependency / failed essentiality screens.
• search_ancestry_specific_failuresAncestry-specific CRISPR failures.
• search_developability_failuresAntibody developability failures.
• search_failed_clinical_antibodiesDiscontinued/terminated clinical antibodies.
• search_failed_peptide_therapeuticsFailed peptide therapeutics.
• search_peptide_stability_issuesPeptide stability/half-life failures.
• search_failed_protacsPROTACs that failed degradation/ternary/permeability.
• search_protac_e3_issuesPROTAC E3-ligase recruitment / ternary failures.
• search_failed_oligonucleotidesASOs/siRNAs that failed engagement/developability.
• search_oligo_delivery_failuresOligonucleotide delivery failures.
• search_failed_vaccinesFailed/terminated vaccines (by pathogen/indication).
• search_vaccine_immunogenicity_failuresFailed vaccine immunogen designs.
• search_failed_adcsADCs that failed at any stage.
• search_adc_linker_failuresADC failures attributed to linker chemistry.
• search_failed_bispecificsBispecifics that failed at any stage.
• search_bispecific_format_failuresBispecific format/engineering failures.
• search_admet_failures_all_modalitiesADMET failures across ALL modalities.
• search_drug_drug_interaction_failuresDrug-drug interaction failures.
• search_mechanism_failuresApproaches that failed for a mechanism (by target).
• search_failed_replicationsFindings that failed to replicate.
• search_safety_failuresClinical/preclinical safety failures across modalities.
• search_target_historyALL failed approaches against a target across every modality.
• search_indication_historyALL failed approaches for an indication across every modality.
• search_pathogen_historyVaccine + antimicrobial + antibody failures for a pathogen.
• get_compoundA compound (structure, name, max clinical phase) + its full negative profile across modalities/sources.
• get_finding_provenanceFull provenance + detail for a single finding by id.
• get_target_landscapeTarget 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533).
• list_top_targetsCoverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other).
• list_modelsSummary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC.
• get_model_cardPer-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533).
• get_coveragePer-modality and per-source coverage stats (honest Phase-1 numbers).

配置到 Claude / Cursor

{
  "mcpServers": {
    "remote-ai-nullary-nullary": {
      "type": "http",
      "url": "https://mcp.nullary.ai/mcp"
    }
  }
}